Profile Detail
W. Barry Edwards, PhD
Assistant ProfessorE-Mail:
Interest (in 3 to 10 words):
| Education | University of North Carolina, Asheville, NC-B.S.-1985-Chemistry Florida State University, Tallahassee, FL-M.S.-1990-Organic Chemistry Washington University, St. Louis, MO-Ph.D.-1999 Bioorganic Chemistry |
| University of North Carolina | |
| Medical / Graduate School | Florida State University, MS Washington University, PhD |
| Residency | |
| Clinical / Post-doctoral Fellowship | |
| Current | American Chemical Society (1986-present) Society of Molecular Imaging (2008-present) Society of Nuclear Medicine (2010-present) |
| Specialties & Programs |
PET Optical Nuclear Medicine Pre-clinical |
| Clinical Interest | |
| Research Interest | Development optical probes for optical imaging of enzyme activity Development of phage displayed and combinatorial peptide libaries for discovery of ligands for molecular imaging |
| Selected Publications | 1)Spradau TW, Edwards WB, Anderson CJ, Welch MJ, Katzenellenbogen JA: Synthesis and biological evaluation of Tc-99m-cyclopentadienyltricarbonyltechnetium-labelled octreotide. Nuclear Medicine and Biology, 1999; 26: 1. 2)Edwards WB, Anderson CJ, Fields GB, Welch MJ: Evaluation of radiolabeled type IV collagen fragments as potential tumor imaging agents. Bioconjugate Chemistry, 2001; 12: 1057. 3)Edwards WB, Reichert DE, dAvignon DA, Welch MJ: beta-cyclodextrin dimers as potential tumor pre-targeting agents. Chemical Communications, 2001; 1312. 4)Edwards WB, Xu B, Akers W, Cheney PP, Liang K, Rogers BE, Anderson CJ, Achilefu S: Agonist-Antagonist dilemma in molecular imaging: evaluation of a monomolecular multimodal imaging agent for the somatostatin receptor. Bioconjugate Chemistry, 2008;19: 192. 5)Zhang Z; Fan J, Cheney PP, Berezin M, Akers W, Shen D, Edwards WB, Culver J, Achilefu S: Homologous Donor-Acceptor Near-Infrared FRET System for Monitoring Enzyme Activities. Molecular Pharmaceutics, 2009,6; 416. 6)Edwards WB, Akers WJ, Ye Y, Cheney PP, Bloch S, Laforest R, Achilefu S: Multimodal imaging of integrin receptor-positive tumor by bioluminescence, fluorescence, gamma scintigraphy, and SPECT methods using a cyclic RGD peptide labeled with a near infrared fluorescent dye and a radionuclide. Molecular Imaging, 2009; 8:101 7)Berezin MY, Guo K, Teng B, Edwards WB, Anderson CJ, Vasalatiy O, Gandjbakhche A, Griffiths GL, Achilefu S: Radioactivity-Synchronized Fluorescence Enhancement Using a Radionuclide Fluorescence-Quenched Dye. J American Chemical Society, 2009; 131:9198. 8)Lee H, Cheney PP, Akers WJ, Edwards WB, Liang K, Achilefu S: Integrin-targeted dual PET/DOT probe for in vivo tumor imaging and caspase 3-activity via an efficient fluorescence quenching mechanism. J Biomedical Optics, 2009; 14: 040507. 9)Chen R, Parry JJ, Akers WJ, Achilefu S, Edwards WB, Rogers BE: Multimodality imaging of gene transfer using a receptor-based reporter gene. J Nucl Med, 2010; 51: 1456. 10)Solomon M, Guo K, Sudlow G, Berezin M, Edwards WB, Achilefu S, Akers, W Detecton of enzyme activity in orthotopic murine breast cancer by fluorescence lifetime imaging using FRET-based molecular probes, J Biomedical Optics, 2011 in press. |
| Honors and Awards |
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| PubMed Publications | See a listing of publications on PubMed, a service of the National Library of medicine. |
