Profile Detail

Alberto Vazquez, PhD

Research Assistant Professor

Interest (in 3 to 10 words):

Education Rensselaer Polytechnic Insititute, B.S. in Biomedical Engineering, 1994

University of Pittsburgh, M.S. in Bioengineering, 1997

University of Michigan, Ph.D. in Biomedical Engineering, 2005
B.S. in Biomedical Engineering, Rensselaer Polytechnic Institute
Medical / Graduate School M.S. in Bioengineering, University of Pittsburgh
Ph.D. in Biomedical Engineering, University of Michigan
Clinical / Post-doctoral Fellowship Post-Doctoral Scholar, Departments of Neurobiology and Radiology, University of Pittsburgh
Current Society for Magnetic Resonance in Medicine (1996-present)
Organization for Human Brain Mapping (1997-present)
Biomedical Engineering Society (2001-present)
Society for Cerebral Blood Flow and Metabolism (2002-present)
Society for Neuroscience (2007-present)
& Programs
Clinical Interest Brain, Alzheimer's disease, Neuro MR, Stroke, Neurodegeneration,
Research Interest My research program focuses on neural, vascular and metabolic imaging of normal brain function in vivo with extensions to neurological pathologies, especially Alzheimer’s disease. I use an array of computational and experimental methodologies, such as linear/non-linear modeling and characterization of biological sytems, optical/fluorescence imaging, two-photon microscopy, calcium imaging, optogenetics and magnetic resonance imaging, to assess nervous system function and dysfunction.
Selected Publications   Vazquez AL, Fukuda M, Crowley JC, Kim SG (2014). Neural and Hemodynamic Responses Elicited by Forelimb- and Photo-stimulation in Channelrhodopsin-2 Mice: Insights into the Hemodynamic Point Spread Function, Cerebral Cortex, 24: 2908-19. PMID: 23761666 PMC4193461.

Kozai TD, Catt K, Gugel ZV, Olafsson VT, Vazquez AL, Cui XT (2014). Mechanical Failure Modes of Chronically Implanted Planar Silicone-based Neural Probes for Laminar Recording, Biometarials, 37C: 25-39. PMID: 25453935

Vazquez AL, Murphy M, Kim SG (2014). Neural and Physiological Correlation to Hemodynamic Resting-state Oscillations in Health and Disease, Brain Connectivity, 4: 727-740. PMID: 25300278 PMC4238243

Kozai TD, Vazquez AL, Weaver CL, Kim SG, Cui XT (2012). In vivo two-photon microscopy reveals immediate microglial reaction to implantation of microelectrode through extension of processes, Journal of Neural Engineering, 17: 9. PMID: 23075490 PMC3511663

Vazquez, A. L., Fukuda, M., Kim, S. G. (2012). Evolution of the dynamic changes in functional cerebral oxidative metabolism from tissue mitochondria to blood oxygen. J Cereb Blood Flow Metab, 32(4), 745-58.

Vazquez, A. L., Masamoto, K., Fukuda, M., & Kim, S. G. (2010). Cerebral oxygen delivery and consumption during evoked neural activity. Front Neuroenergetics, 2, 11.

Vazquez, A. L., Fukuda, M., Tasker, M. L., Masamoto, K., & Kim, S. G. (2010). Changes in cerebral arterial, tissue and venous oxygenation with evoked neural stimulation: implications for hemoglobin-based functional neuroimaging. J Cereb Blood Flow Metab, 30(2), 428-439.

Kim, T., Masamoto, K., Fukuda, M., Vazquez, A., & Kim, S. G. (2010). Frequency-dependent neural activity, CBF, and BOLD fMRI to somatosensory stimuli in isoflurane-anesthetized rats. Neuroimage, 52(1), 224-233.

Masamoto, K., Fukuda, M., Vazquez, A., & Kim, S. G. (2009). Dose-dependent effect of isoflurane on neurovascular coupling in rat cerebral cortex. Eur J Neurosci, 30(2), 242-250.

Hernandez-Garcia, L., Vazquez, A. L., & Rowe, D. B. (2009). Complex-valued analysis of arterial spin labeling-based functional magnetic resonance imaging signals. Magn Reson Med, 62(6), 1597-1608.

Gulani, V., Adusumilli, S., Hussain, H. K., Vazquez, A. L., Francis, I. R., & Noll, D. C. (2008). Apparent wall thickening of cystic renal lesions on MRI. J Magn Reson Imaging, 28(1), 103-110.

Vazquez, A. L., Masamoto, K., & Kim, S. G. (2008). Dynamics of oxygen delivery and consumption during evoked neural stimulation using a compartment model and CBF and tissue P(O2) measurements. Neuroimage, 42(1), 49-59.

Masamoto, K., Vazquez, A., Wang, P., & Kim, S. G. (2008). Trial-by-trial relationship between neural activity, oxygen consumption, and blood flow responses. Neuroimage, 40(2), 442-450.

Vazquez, A. L., Lee, G. R., Hernandez-Garcia, L., & Noll, D. C. (2006). Application of selective saturation to image the dynamics of arterial blood flow during brain activation using magnetic resonance imaging. Magn Reson Med, 55(4), 816-825.

Vazquez, A. L., Cohen, E. R., Gulani, V., Hernandez-Garcia, L., Zheng, Y., Lee, G. R. et al. (2006). Vascular dynamics and BOLD fMRI: CBF level effects and analysis considerations. Neuroimage, 32(4), 1642-1655.

Vazquez AL, Lee GR, Hernandez L, Noll DC (2006). Application of Selective Saturation to Image the Dynamics of Arterial Blood Flow During Brain Activation Using MRI, Magnetic Resonance in Medicine, 55:816-825.

Wager TD, Vazquez AL, Hernandez-Garcia L, Noll DC (2005). Accounting for nonlinear effects in fMRI: Parameter estimates and a model for prediction in rapid event-related studies, NeuroImage, 25:206-18.

Hernandez-Garcia L, Lee GR, Vazquez AL, Yip CY, Noll DC (2005). Quantification of Perfusion FMRI Using a Numerical Model of Arterial Spin Labeling that Accounts for Dynamic Transit Time Effects, Magnetic Resonance in Medicine, 54:955-64.

Hernandez-Garcia L, Lee GR, Vazquez AL, Noll DC (2004). Fast, Pseudo-Continuous Arterial Spin Labeling Using a Two-Coil System for Functional Imaging, Magnetic Resonance in Medicine, 51:577-85.

Vazquez AL, Noll DC (1998). Non-linear Aspects of the Blood Oxygenation Response in Functional MRI, NeuroImage, 7:108-18, 1998. PMID: 9558643

Noll DC, Genovese CR, Vazquez AL, OBrien JL, Eddy WF (1998). Evaluation of Respiratory Artifact Correction Techniques in Functional MRI Using Receiver Operator Characteristic Analyses, Magnetic Resonance in Medicine, 40:633-39.
Honors and  
ScholarPower Academic Award, University of Michigan (2005)
National Research Service Award NIH/NINDS (F32; 2006-2009)
Gordon Research Conference, Brain Energy Metabolism 2012, Hot Topics Best Research
PubMed Publications   See a listing of publications on PubMed, a service of the National Library of medicine.