Profile Detail

Xiang He, PhD

Assistant Professor

Interest (in 3 to 10 words):

Education Peking University, P.R. China, BSc in Physics, 1992

University of Waterloo, Canada,MSc in Physics, 1997

University of Waterloo, Canada,PhD in System Design Engineering, 2002
Peking University, P.R. China
Medical / Graduate School University of Waterloo, Canada,MSc
University of Waterloo, Canada,PhD
Clinical / Post-doctoral Fellowship Mallinckrodt Institute of Radiology, Washington University in St Louis, Staff Scientist

Mallinckrodt Institute of Radiology, Washington University in St Louis, Instructor
Current International Society of Magnetic Resonance in Medicine (2005-present)
Radiological Society of North American (2010-present)
American Diabetes Association (2012-present)
& Programs
Clinical Interest Functional MRI; Brain tumor hypoxia; Brain BBB permeability; Kidney functional MR imaging; Prostate imaging;
Research Interest My research interest is on the biophysical mechanisms of MR signal formation and evolution in biological systems and development of novel MRI techniques allowing for the in vivo quantification of tissue function such as oxygen metabolism and water exchange in brain and kidney in health and disease. Research topics include quantitative BOLD MRI theory in rest state and during functional activation; mechanism on tissue MR signal frequency contrast in gradient-recalled echo (GRE) images; T1ρ quantification techniques for body MR imaging; Novel MR based non-invasive quantification of kidney functions, i.e. glomerular filtration rate (GFR) and kidney oxygen metabolism; Novel MR imaging biomarker for prostate cancer.
Selected Publications   He Xiang, Yablonskiy DA. Quantitative BOLD: mapping of human cerebral deoxygenated blood volume and oxygen extraction fraction: default state. Magnetic Resonance in Medicine 2007, 57(1):115-126.

He Xiang, Zhu M and Yablonskiy DA (2008). Validation of oxygen extraction fraction measurement by qBOLD technique, Magnetic Resonance in Medicine 2008, 60(4): 882-8.

He Xiang, Yablonskiy DA. Biophysical mechanisms of phase contrast in gradient echo MRI, Proc Natl Acad Sci USA (PNAS) 2009; 106(32):13558-63.

He Xiang, Raichle ME and Yablonskiy DA, Probing perfusion water transport by ASL-qBOLD technique, J Cereb Blood Flow Metab 2009;S29(S1):S88

Luo J, He Xiang, d'Avignon A, Ackerman J and Yablonskiy DA, Protein-induced water 1H MR frequency shifts: contributions from magnetic susceptibility and exchange, Journal of Magnetic Resonance 2010, 202:102-108.

McCommis K, He Xiang, Abendschein D, Gupte PM, Gropler RJ, Zheng Jie, Cardiac 17O MRI: Towards Direct Quantification of Myocardial Oxygen Consumption, Magnetic Resonance in Medicine, Magnetic Resonance in Medicine 2010, 63(6), pp. 1442-7.

He Xiang, Raichle ME and Yablonskiy DA, Transmembrane dynamics of water exchange in human brain, Magnetic Resonance in Medicine, 2012, 67(2), pp. 562-571.

He Xiang, Editorial Focus: Functional MR Imaging of Kidney -- Novel Approaches to Monitoring Renal Physiology, Am J. Physiol Renal Physiol, 2012, doi: 10.1152/ajprenal.00224.2012;

Yablonskiy DA, Sukstanski AL, He Xiang, BOLD-based Techniques for Quantifying Brain Hemodynamic and Metabolic Properties Theoretical Models and Experimental Approaches, NMR in Biomed, DOI: 10.1002/nbm.2839

He Xiang, Aghayev Ayaz, Gumus Serter and Bae Ty, Estimation of Single-Kidney Glomerular Filtration Rate without Exogenous Contrast Agent, MRM, under review.

He Xiang, Gumus Serter, Aghayev Ayaz, Yablonskiy DA and Bae Ty, Mapping of Intra-Renal Oxygenation by Quantitative BOLD, MRM, under review.
Honors and  
PubMed Publications   See a listing of publications on PubMed, a service of the National Library of medicine.