The University of Pittsburgh's PET Research Facility is housed in approximately 12,000 sq. feet of dedicated research space on the 9th floor of Presbyterian University Hospital's B-wing. Included in this space are a 3000 sq. ft. Radiochemistry Laboratory, three 500 sq. ft. scanner bays, two control rooms, offices for PET Facility faculty and staff.
The PET Radiochemistry Laboratory produces radionuclides and investigational radiopharmaceuticals for PET imaging using a dedicated Siemens Eclipse HP medical cyclotron installed in the 4Q 2010, which replaced a legacy CTI RDS-112 system originally sited in 1992. The Eclipse HP is an 11 MeV negative-ion cyclotron equipped with targetry for producing the positron-emitting radionuclides carbon-11, fluorine-18, nitrogen-13, and oxygen-15. Supported Radiosynthetic apparatus includes a G.E. Healthcare TRACERLab™ FX MeI gas-phase [C-11]methyl-iodide system, two TRACERLab™ FX M carbon-11 incorporation platforms, and a FASTlab™ fluorine-18 incorporation platform, which provides the desired short duty cycles and repeat production capabilities needed to maximize the production capabilities of the cyclotron and achieve the high specific activity radiopharmaceutical productions required for human and preclinical neuroreceptor imaging studies. Modules for [O-15]-labeled gases (oxygen, carbon monoxide, and carbon dioxide) are in use. A Victoreen gas delivery system provides [O-15]-labeled gases via a remotely operated inhalation system connected to the PET scanning rooms. High specific activity [C-11]-labeled carbon dioxide and carbon monoxide gases are also available. The radiochemistry laboratory is equipped with three full-size Capintec-brand hot cells fitted with three pairs of remote manipulators for operator-assisted radiopharmaceutical productions. In addition, there are two large stacked Capintec mini-cells and four smaller Capintec mini-caves for routine automated productions, three radioisotope fume hoods, five organic synthesis fume hoods, two laminar flow hoods, twelve radio-HPLC systems (including gradient pumps, variable wavelength UV detectors, two photodiode array detectors, a refractive index detector, an electrochemical detector, and about 20 radioactivity detectors), and miscellaneous analytical equipment including a radio-TLC scanner, radio-GC, Varian Saturn GC-MS, two gamma well counters (Packard Cobra model 5003), a Fuji BAS-5000 phosphor imager, and FTIR, and UV/vis spectrometers.